Menthol as a conditioned cue for nicotine reward

Menthol is the most widely used additive for tobacco products. It is also one of the most preferred flavors of electronic cigarettes. Using licking as the operant behavior, we are studying the role of menthol as a conditioned cue for nicotine self-administration. Our data showed that the cooling sensation of menthol is an unique sensory cue that supports nicotine self-administration and induces long-lasting drug-seeking behavior.